In this study, In-vitro antioxidant activity of hexane (PAHE), ethyl acetate (PAEA), methanolic (PAME) extracts and isolated lignans (phyllanthin (PAPH) & hypophyllanthin (PAHP)) of P.amarus aerial parts was investigated by using Superoxide radical, Hydroxyl radical and DPPH radical scavenging methods. Phyllanthus amarus Schum. & Thonn. is a small herb well known for its medicinal properties. P. amarus is an important plant of Indian Ayurvedic system of medicine for treatment of several ailments. The tested extracts and isolated lignans showed dose dependent inhibition of in vitro free radical generation of superoxide anion, hydroxyl radical and DPPH radicals. The results clearly indicated the free radical scavenging activity of tested extracts and lignans of P.amarus aerial parts, this activity is comparable with that of the standard drug ascorbic acid.
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